l-HISTIDINAL, A BIOSYNTHETIC PRECURSOR OF HISTIDINE

Histidine biosynthetic pathway in Staphylococcus aureus.

Coordinate Repression of the Synthesis of Four Histidine Biosynthetic Enzymes by Histidine.

Introduction.-In several instances, the rate of synthesis of the enzymes of a biosynthetic pathway appears to be regulated by the size of the pool of the end product of that pathway.1-4 This phenomenon has been called enzyme repression.2 We have observed repression by histidine during the investigation of the histidine biosynthetic enzymes in histidine-requiring mutants of Salmonella typhimuriu...

2-Fluoro-l-histidine

The title compound, C(6)H(8)FN(3)O(2), an analog of histidine, shows a reduced side-chain pK(a) (ca 1). The title structure exhibits a shortening of the bond between the proximal ring N atom and the F-substituted ring C atom, indicating an increase in π-bond character due to an inductive effect of fluorine.

Calcemic fraction-A: biosynthetic peptide precursor of parathyroid hormone.

Calcemic fraction-A (CF-A) is a biologically active, hypercalcemic and bone resorptive peptide, which was detected in, and isolated from, bovine parathyroid glands [Hamilton et al. (1971) Endocrinology 89, 1440-1447]. It has been further purified, and its relationship to parathyroid hormone clarified. The peptide is present in fresh glands at a concentration of about 3 mug/g (parathyroid hormon...

Histidine biosynthetic pathway and genes: structure, regulation, and evolution.

Centro di Endocrinologia ed Oncologia Sperimentale del Consiglio Nazionale delle Ricerche, Dipartimento di Biologia e Patologia Cellulare e Molecolare ‘‘L. Califano,’’ Università degli Studi di Napoli ‘‘Federico II,’’ I-80131 Naples, and Dipartimento di Biologia Animale e Genetica, Università degli Studi di Firenze, I-50125 Firenze, Italy, and Departamento de Biologia, Faculdad de Ciencias, Uni...